Articles tagged Genomics
(78 results)

Every scientist is familiar with the p-value: it’s one of the most commonly used metrics in statistics to evaluate the likeliness that an observed relationship is due to chance. Typically, a cutoff is set at p=0.05, such that any p-value of greater than 0.05 means the result is deemed “not statistically significant”—a heartbreaking outcome for…

When a mutation arises in an egg or sperm cell, it could be evolutionarily important. But if a mutation occurs in somatic tissue instead, the result could be cancer. Mutations in the germline and soma not only have contrasting consequences, they also arise at different rates that may reflect the balance of DNA damage and…

At first glance, the yeast Candida krusei seems as innocuous as microbes come: it’s used for fermenting cocoa beans and gives chocolate its pleasant aroma. But it’s increasingly being found as a pathogen in immunocompromised patients—and C. krusei infections aren’t always easy to cure. This yeast is naturally resistant to fluconazole, a first-line antifungal that’s…

A green, iridescent bee perches on a pink flower, extending its proboscis to reach the sweet nectar inside. He’s not just after a meal—he’s also collecting fragrant substances to store inside his hollow rear legs. Later, he’ll buzz his wings to release the aroma with the hope of attracting a mate. The cover of the…

It’s surprisingly common for babies to be born missing one or both kidneys; an estimated one in one thousand babies are born with a single kidney. Called renal agenesis, this condition is fatal if both kidneys are missing, and having just one can also lead to serious health problems like hypertension and early renal failure.…

When a group of microorganisms needs to stick together, they build a biofilm. The cells cement themselves together onto a surface, forming durable structures that are notoriously hard to remove. In a medical setting, biofilms can contribute to dangerous antibiotic resistance. In the August issue of G3, Cromie et al. use a yeast model to…

Genes involved in male reproduction tend to evolve rapidly. This has been observed in many different species and is thought to be due to sexual selection as males compete over mating opportunities. But in the August issue of GENETICS, Whittle and Extavour present results that flip this paradigm upside down. They find that in the…

Rice is one of the most important food crops on earth. Like many other plants, the genome of this critical global species is dominated by transposable elements—selfish genes that multiply themselves to the detriment of their host. In the June issue of G3, Zhang and Gao analyze the genomic long terminal repeat (LTR) retrotransposon content…

Humans built the modern world with the help of domestic plants and animals. A byproduct of our many domestication experiments is a series of excellent long-term controlled evolutionary comparisons that are helping geneticists understand adaptation. In a study published in the May issue of G3, Fleming et al. identify genomic regions under natural selection in…

Multiparental populations (MPPs) have brought a new era in mapping complex traits, as well as new analytical challenges. To face these challenges and encourage innovation, the GSA journals launched the ongoing Multiparental Populations series in 2014. This month’s issues of GENETICS and G3 feature a bumper 16 MPP articles, timed to celebrate a new easy-to-use…

Illuminating the cover of the May issue of G3 is a lake-dwelling filter feeder no more than a couple millimeters long. This microcrustacean—Daphnia pulex, also known as the water flea—is an important model organism, especially in ecological genetics. But despite Daphnia’s status as a model organism, no one had examined its population genomics until now.…