New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including...

Cancer GeneticsDrosophilaFundamental ResearchG3 JournalHuman DiseaseModel Organisms

Yeast study suggests faulty proofreading is not to blame for link between cancer and DNA polymerase ε variants. Accurate DNA replication is a matter of...

Cancer GeneticsFundamental ResearchG3 JournalHuman DiseaseYeast

When a mutation arises in an egg or sperm cell, it could be evolutionarily important. But if a mutation occurs in somatic tissue instead, the...

Cancer GeneticsGenome IntegrityGenomicsHuman Evolution & Variation

Cancer profoundly scars the genome of an affected cell. Amplification and overexpression of chunks of DNA sequence are common—but it’s not always clear whether these...

Cancer GeneticsGenetics JournalHuman DiseaseYeast

The detonation of atomic bombs over the Japanese cities of Hiroshima and Nagasaki in August 1945 resulted in horrific casualties and devastation. The long-term effects...

Cancer GeneticsGenetics JournalHuman DiseaseScience Policy

With about 1 in 8 women in the United States expected to develop breast cancer in their lifetime, breast cancer remains the most common malignancy...

Cancer GeneticsGenetics JournalHuman Disease

The mutations that drive cancer formation are often found in “hub” genes that regulate many aspects of cell growth and survival. But these key genes...

Cancer GeneticsChromosomesGenetics JournalGenome IntegrityHuman Disease