New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including...


A new fruit fly model of Leigh syndrome reveals the importance of mtDNA variation. Inherited mitochondrial disorders pose a perplexing problem to researchers and clinicians:...


The “hyperspin” long-range enhancer deletion recapitulates disease phenotypes. In recent years, improvements in genetic testing have made it much easier to discover the causes of...


Yeast study suggests faulty proofreading is not to blame for link between cancer and DNA polymerase ε variants. Accurate DNA replication is a matter of...


In 1983, the median lifespan for people born with Down syndrome in the US was only 25 years. Today, due to better treatments for some...


Rhinocladiella mackenziei is a fungus that infects the human brain. It is the most common cause of neurological fungal infections in arid regions of the...


There’s no doubt that an extra copy of chromosome 21 is what causes Down syndrome. There’s a lot of doubt, however, over which particular gene—or...


From fish tank to bedside

February 28, 2018

Yeast and zebrafish are among the lab organisms being recruited to the search for rare disease cures. Rare diseases are not so rare. About 300...


Beer, doughnuts, and genetics textbooks have one thing in common: they were all made possible by collaborations between humans and yeast. Our fungal ally Saccharomyces...


The Genetics Society of America (GSA) is pleased to announce that Philip Hieter is the recipient of the 2018 George W. Beadle Award, bestowed in...