A suppressor screen in C. elegans uncovers previously unknown flexibility in the genetics underlying extracellular membranes. In nearly all animal tissues, thin barriers called basement...
C. elegansFundamental ResearchGenetics JournalModel Organisms
New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including...
Cancer GeneticsDrosophilaFundamental ResearchG3 JournalHuman DiseaseModel Organisms
A new fruit fly model of Leigh syndrome reveals the importance of mtDNA variation. Inherited mitochondrial disorders pose a perplexing problem to researchers and clinicians:...
DrosophilaFundamental ResearchGenetics JournalHuman DiseaseModel OrganismsRare Diseases
Photosensitive alternative splicing of a malt fly circadian clock gene varies between northern and southern populations. Over the course of a day, most organisms undergo...
DrosophilaEvolutionFundamental ResearchG3 JournalGene ExpressionInsects
The “hyperspin” long-range enhancer deletion recapitulates disease phenotypes. In recent years, improvements in genetic testing have made it much easier to discover the causes of...
Fundamental ResearchGenetics JournalHuman DiseaseMouse & RatRare Diseases
Yeast study suggests faulty proofreading is not to blame for link between cancer and DNA polymerase ε variants. Accurate DNA replication is a matter of...
Cancer GeneticsFundamental ResearchG3 JournalHuman DiseaseYeast
The Y chromosome has an unanticipated role in sex-biased intron retention in Drosophila. Differences between males and females in sexually dimorphic species stem in part...
Model organism researchers face shared challenges in communicating the value of their work. How do you get policymakers to fund research on a microscopic organism...
AdvocacyCiliatesFundamental ResearchPublic OutreachScience Communication
Monomethylated H3K27 is more than just an intermediate. We often talk about biological traits as if they’re written in our DNA, but some of them...
Recent evolution of simple germ–soma division in a green alga sheds light on the early stages of complex multicellular life. Among evolution’s greatest innovations are...
