Parent-of-origin effects help determine how lab rats respond to stress. Although your father and mother each contribute a copy of your genes, these copies don’t...
For the first time in nearly 15 years, the rat genetic map has been updated. Genetic maps help us navigate uncharted data, but to successfully...
Imprinted genes can have oppositional effects on adult behavior in mice. Mammalian genomes show the marks of a genetic tug-of-war between mothers and fathers. These...
The “hyperspin” long-range enhancer deletion recapitulates disease phenotypes. In recent years, improvements in genetic testing have made it much easier to discover the causes of...
Fundamental ResearchGenetics JournalHuman DiseaseMouse & RatRare Diseases
A reanalysis of genes tied to life span in mice reveals only a select few affect aging. Like it or not, you are always getting...
Biologists rely on animal models to answer important questions that can’t be addressed with cells in a dish. Often, these animals are deliberately inbred; a...
BioinformaticsComplex Traits & Quantitative GeneticsG3 JournalMammalsModel OrganismsMouse & RatPopulation GeneticsReproducibility
After surviving breast cancer, almost forty percent of female patients are affected by primary ovarian insufficiency (POI). This condition, in which ovaries don’t produce normal...
Epilepsy is characterized by recurrent seizures, often with no immediately obvious cause. In the August issue of G3, Ferland et al. use a genome-wide association...
Complex TraitsG3 JournalHuman DiseaseMouse & RatNeuroscience
Fascinating discoveries sometimes emerge from the most daunting of experimental roadblocks. Designed to generate over 1,000 recombinant inbred mice lines for genetic mapping, the Collaborative...
ChromosomesComplex TraitsEvolutionG3 JournalGenetics JournalGenetics of SexMammalsModel OrganismsMouse & RatMultiparental Populations
Multiparental populations (MPPs) have brought a new era in mapping complex traits, as well as new analytical challenges. To face these challenges and encourage innovation,...
BioinformaticsChromosomesComplex TraitsEvolutionGenetics JournalGenomicsMouse & RatMPP PeopleMultiparental PopulationsPopulation Genetics
