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Articles tagged Genetics Journal
(301 results)
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How nematodes sense danger
In critical situations, communication can mean the difference between life and death. If our house goes up in flames, we don’t need to smell smoke to be alarmed as long as someone yells, “Fire!” This isn’t unique to humans; even creatures with much less sophisticated means of sharing information have ways of telling each other…
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An overactive immune system alters the gut microbiome in Drosophila
Taking probiotics might be the latest health fad, but for people with inflammatory bowel diseases, the microbiome is a more serious matter. With these autoimmune diseases, the composition of the gut microbiome can have critical health consequences. In the June issue of GENETICS, Mistry et al. use fruit flies to determine whether immune system activity…
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The mouse lemur: a new genetic model organism
Palm fronds crunch under a researcher’s foot as she hikes through a rainforest in Madagascar looking for a spot to release a tiny, omnivorous ball of fur with bulging eyes—a mouse lemur. This creature, the smallest type of primate, is an important research subject: it has just yielded a blood sample, skin cells, and an…
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Housekeeping genes escape miRNA repression through alternative polyadenylation
Changing where the polyA tail is added to an mRNA transcript can fine-tune the tissue-specific expression of many genes, reports a Caenorhabditis elegans study published in the June issue of GENETICS. Blazie et al. show alternative polyadenylation (APA) allows transcripts to evade microRNA (miRNA) silencing in some tissues, allowing for tissue-specific expression of those genes.…
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Fido won’t fetch? Maybe it’s his pedigree
Whether a thunderclap drives your dog to cower behind the couch or leaves it unfazed may be determined in part by genetics. In the June issue of GENETICS, Ilska et al. analyze genetic contributors to canine personality traits—such as fear of loud noises—using owners’ reports of their pets’ behavior. The researchers chose this survey-based method…
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Behind the cover: Male infertility in the mouse Collaborative Cross
Fascinating discoveries sometimes emerge from the most daunting of experimental roadblocks. Designed to generate over 1,000 recombinant inbred mice lines for genetic mapping, the Collaborative Cross (CC) project unearthed astounding variation in male fertility when nearly 95% of the highly inbred CC lines went extinct. As part of the Multiparental Populations series in the June…
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June GENETICS Highlights
Check out the June issue of GENETICS by looking at the highlights or the full table of contents! ISSUE HIGHLIGHTS Alternative polyadenylation directs tissue-specific miRNA targeting in Caenorhabditis elegans somatic tissues, pp. 757-774 Stephen M. Blazie, Heather C. Geissel, Henry Wilky, Rajan Joshi, Jason Newbern, and Marco Mangone Alternative polyadenylation (APA) is observed in virtually all metazoans and…
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MPP People: Elizabeth King
Multiparental populations (MPPs) have brought a new era in mapping complex traits, as well as new analytical challenges. To face these challenges and encourage innovation, the GSA journals launched the ongoing Multiparental Populations series in 2014. This month’s issues of GENETICS and G3 feature a bumper 16 MPP articles, timed to celebrate a new easy-to-use…
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Explore the new Multiparental Populations resource at GENETICS and G3
The GSA Journals are proud to announce a brand new site for our Multiparental Populations (MPP) series. We’re celebrating this redesigned, easy-to-browse site with the addition of sixteen new papers from both journals to the series. As the field of genetics has grown, the rapid development of genomic technologies has given researchers the ability to…
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MPP People: Andrew Morgan
Multiparental populations (MPPs) have brought a new era in mapping complex traits, as well as new analytical challenges. To face these challenges and encourage innovation, the GSA journals launched the ongoing Multiparental Populations series in 2014. This month’s issues of GENETICS and G3 feature a bumper 16 MPP articles, timed to celebrate a new easy-to-use…
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Neural networks dive deep to locate proteins
As in real estate, so in cell biology: location is key. Knowing where a protein localizes in a cell gives insight into its function, and new research published in G3 describes a method to accurately identify a protein’s subcellular localization through high-throughput microscopy and machine learning. To determine a protein’s subcellular localization, researchers can tag…