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Science & Publishing

  • Science & Publishing

    Rodents of unusual size: Genetic complexity underlies evolution of body size in island mice

      Genetic analysis of an island population of mice reveals that 19 quantitative trait loci are responsible for their impressive size. Island populations of animals, isolated from their mainland relatives, have given us insight into evolution from the very birth of the field. In fact, studying finches on the Galápagos Islands helped Charles Darwin establish…

  • Science & Publishing

    New in G3: association mapping, amino acid usage, and appendage development

    Check out the October issue of G3! Meeting Report Meeting Report on the Challenge of Inference from Genome to Phenome Bevan Emma Huang, Antonio Reverter, Ian Purvis, and Scott Chapman G3 October 2015 5:1945-1947; doi:10.1534/g3.115.019182 Full Text | Full Text (PDF) | Supporting Information Investigations Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon…

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    Conversations in Genetics talks with Mary-Claire King

    The Conversations in Genetics project, led by former GSA President Rochelle Easton Esposito, has a new in-depth interview of Mary-Claire King by Evan Eichler. As described in the video “Talking with Mary-Claire King,” Dr. King is American Cancer Society Professor of Genome Sciences and Medicine at the University of Washington in Seattle. Her innovative studies of human genetics…

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    Authentic ethics in synthetic biology

    While the science behind the synthetic yeast genome project is cutting edge, the ethical questions surrounding it aren’t new. The scientists of the Sc2.0 project have a goal that sounds akin to science fiction – they’re working toward building a completely synthetic yeast genome. This new strain of Saccharomyces cerevisiae, affectionately named Sc2.0, will be…

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    Genetic tinkering reveals new parts of a molecular motor’s transmission

    Neurons actively shuttle membranous cargos called “organelles” along microtubule tracks using motor proteins that are essentially molecular engines. The motor proteins literally walk along the tracks, shouldering their cargos. Research published in two back-to-back papers in the September issue of GENETICS reveals a neuron-specific transmission system for regulating one of the motors. The microtubule tracks are…

  • National Library of Medicine
    Science & Publishing

    NIH seeking new director for National Library of Medicine

    The National Institutes of Health (NIH) is seeking applications from exceptional candidates to be the next director of NIH’s National Library of Medicine (NLM). NLM is the world’s largest biomedical library that maintains and makes available a broad range of print and electronic resources. Current NLM databases include GenBank, PubMed, and ClinicalTrials.gov. Following from the…

  • Science & Publishing

    Exome sequencing: Giving researchers more bang for their buck

    Over the last decade, advances in next-generation sequencing technology have given rise to many findings increasing our understanding of human disease and natural variation within species. Sequencing of the exome, the small fraction of the genome encompassing all exons of protein coding genes, has gained popularity as an inexpensive alternative to sequencing the entire genome.…

  • Science & Publishing

    Biocurators: Behind the Data

    Today’s guest post was contributed by Maria Costanzo of Stanford University. She has been a biocurator since before the term was coined and has contributed to genome database projects for a variety of fungi. The views expressed are her own. Follow her on Twitter: @mariaccostanzo.   When someone asks what I do for a living,…

  • Science & Publishing

    Human Genetic Diversity and Social Inequalities

    As ancient humans spread across the globe from their evolutionary birthplace in Africa, they tended to lose a little genetic diversity at each step along the way. New settlements were probably often founded by small groups that carried only a subset of the total diversity present in their homelands. Successive rounds of this “founder effect”…

  • Science & Publishing

    New in GENETICS!

    Check out the September issue of GENETICS! Investigations METHODS, TECHNOLOGY, AND RESOURCES A Male-Specific Genetic Map of the Microcrustacean Daphnia pulex Based on Single-Sperm Whole-Genome Sequencing Xu, Sen, Matthew S. Ackerman, Hongan Long, Lydia Bright, Ken Spitze, Jordan S. Ramsdell, W. Kelley Thomas, and Michael Lynch Abstract|Full Text|Full Text (PDF)|Supporting Information HIGHLIGHTED ARTICLE Computer-Assisted Transgenesis of Caenorhabditis elegans for Deep…

  • Foreground, 60× confocal images of Drosophila S2R+ cultured cells stained for DNA (DAPI; shown in blue) or filamentous Actin (Phalloidin; green). Top left, untreated cells. Clockwise from top right, cells treated with RNAi reagents directed against ncm, Rho1, or hoip. Background photo, 384-well microplates useful for high-throughput luminescence (white plates) or image-based assays (black clear-bottomed plates). Image courtesy of Stephanie Mohr. See Mohr et al. 1919–1924." width="666" height="542
    Science & Publishing

    New in G3: transcriptomics, temperature-sensitive yeast, and TALENs

    Check out the September issue of G3! Investigations SWEEP: A Tool for Filtering High-Quality SNPs in Polyploid Crops Josh P. Clevenger and Peggy Ozias-Akins G3 September 2015 5:1797-1803; Early Online July 6, 2015, doi:10.1534/g3.115.019703 Abstract | Full Text | Full Text (PDF) | Supporting Information Comparative Transcriptome Analysis of the Cosmopolitan Marine Fungus Corollospora maritima Under Two…