Science & Publishing

An evolutionary approach outperforms a design approach in modeling protein sequence variation. Over generations, evolution shapes proteins, leading to variation in their amino acid sequences both between and within species. Despite our ever-increasing knowledge of the physical constraints that guide protein structure, advanced modeling techniques don’t capture the site-specific variability observed in natural proteins. Bafflingly,…

Watch presentations from the conference, including talks from Katie Peichel and Jonathan Pritchard. Now that the dust has settled from the whirlwind of the first ever standalone GSA Population, Evolutionary, and Quantitative Genetics Conference (PEQG18), we’re delighted to be able to share the audio and synched slides from the Keynote and Crow Award sessions. We’re…

diploS/HIC uses machine learning to identify selective sweeps in unphased data. A set of footprints can tell us a lot about the creature that left them—without requiring us to see the creature itself. Footprints can suggest the animal’s size, weight, and stride, and from there, we can extrapolate even more information. Much like soft sand…

Imprinted genes can have oppositional effects on adult behavior in mice. Mammalian genomes show the marks of a genetic tug-of-war between mothers and fathers. These imprinted genes are marked by epigenetic modifications, which means the expression of an imprinted allele depends on whether it was inherited from the mother or the father. A new report…

A suppressor screen in C. elegans uncovers previously unknown flexibility in the genetics underlying extracellular membranes. In nearly all animal tissues, thin barriers called basement membranes anchor outward-facing layers of cells—the linings of lungs, the top layers of skin, the insides of blood vessels—to the connective tissues that support them. Mutations disrupting any major basement…

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2017. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors. Browse the 2017 GENETICS Spotlight. Browse the 2017 G3 Spotlight.  

Expression analysis provides clues about what makes some peanut strains more susceptible to fungal toxin contamination. In 1960, 100,000 turkeys across hundreds of English poultry farms died from aflatoxin contamination in the peanut meal in their feed. Aflatoxin is a potent carcinogen produced by fungi of the genus Aspergillus, which can grow on peanuts. Although…

New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including increased numbers of single nucleotide variants (SNVs) and copy number variants (CNVs). However, a 2014 study on a fruit fly tumor detected no elevation of SNVs or CNVs compared to non-tumor…

A new study reveals genetic changes that affect social behavior in chickens. We have a number of phrases that relate human behavior to that of chickens; for example, when you accuse someone of acting “chicken,” you’re likely calling them a coward. If someone is running around like a chicken with their head cut off, they’re…

Although epigenetic modifications contribute to trait variability, their effect pales in comparison to standing genetic variation. The raw material of evolution is genetic variation, but proponents of the “extended evolutionary synthesis” add a new layer to this model: heritable variation in epigenetics. The packaging and tagging of DNA can alter traits without changing the DNA…

Offshoot of the modENCODE project provides crucial data and strains for understanding gene regulation. Following a multidisciplinary effort spanning six institutions, researchers working on the modERN (model organism Encyclopedia of Regulatory Networks) project have released a powerful resource for biologists studying the fruit fly Drosophila melanogaster and the nematode worm Caenorhabditis elegans. So far, report Kudron,…