Articles tagged Human Disease
(93 results)

One of the major risk factors for autoimmune diseases is being born with two copies of the X chromosome. For example, women—who typically carry two Xs—face around ten times the risk of lupus, while men with lupus are around 15 times more likely than the general population to carry two Xs and a Y (Klinefelter…

We’re pleased to announce that Kym Boycott (Children’s Hospital of Eastern Ontario) has joined the GENETICS Editorial Board. Following Editor-in-Chief Mark Johnston’s call for submissions of human genetics research, Dr. Boycott is a welcome addition to the board’s growing list of editors with expertise in human genetics. Dr. Boycott is a Medical Geneticist at the Children’s Hospital of Eastern Ontario…

In this month’s editorial, the Editors of GENETICS invite submissions of human genetics research articles. To kick off the journal’s call for papers, the October issue features an article by Brooks and Wall et al. identifying the cause of a single-family disorder and a commentary by Phil Hieter and Kim Boycott on the power of model organisms…

In 1979, as the US slid into recession, researchers began systematically crossing eight distinct inbred rat strains. Their goal was to establish a genetically diverse rat colony to serve as a base for phenotype measurements and artificial selection. But the creators of the NIH rat Heterogeneous Stocks (HS) faced major challenges: “…the main one being…

For genome-wide association studies, data is power. The more data you have, the more statistical power you wield to find genetic associations. But are there ways to get more from the data you already have? In the May issue of GENETICS, Kaufman and Rosset describe a testing framework that substantially boosts the power of genome-wide…