Sexual reproduction is scarce in skin infection culprit. While some people love to feel the burn during a workout, we generally seek that sensation in...


An evolutionary approach outperforms a design approach in modeling protein sequence variation. Over generations, evolution shapes proteins, leading to variation in their amino acid sequences...


A suppressor screen in C. elegans uncovers previously unknown flexibility in the genetics underlying extracellular membranes. In nearly all animal tissues, thin barriers called basement...


New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including...


Offshoot of the modENCODE project provides crucial data and strains for understanding gene regulation. Following a multidisciplinary effort spanning six institutions, researchers working on the modERN...


A new fruit fly model of Leigh syndrome reveals the importance of mtDNA variation. Inherited mitochondrial disorders pose a perplexing problem to researchers and clinicians:...


Photosensitive alternative splicing of a malt fly circadian clock gene varies between northern and southern populations. Over the course of a day, most organisms undergo...


The “hyperspin” long-range enhancer deletion recapitulates disease phenotypes. In recent years, improvements in genetic testing have made it much easier to discover the causes of...


Yeast study suggests faulty proofreading is not to blame for link between cancer and DNA polymerase ε variants. Accurate DNA replication is a matter of...


The Y chromosome has an unanticipated role in sex-biased intron retention in Drosophila. Differences between males and females in sexually dimorphic species stem in part...