Three GENETICS articles from 2019 recognized with Editors’ Choice Awards
Congratulations to the winners of the Editors’ Choice Awards for outstanding articles published in GENETICS in 2019! The journal’s Editorial Board considered a diverse range of articles, finding many papers worthy of recognition. After much deliberation, they settled on one exceptional article for each of the three award categories: molecular genetics, population and evolutionary genetics, and quantitative genetics. Check out some of the best GENETICS had to offer in 2019!
EDITORS’ CHOICE AWARD IN MOLECULAR GENETICS
, , , , , , and Belinda S. W. Chang
G protein-coupled receptors (GPCRs) are crucial sensors of extracellular signals in eukaryotes, and direct measurement of GPCR mediated signaling is useful for high-throughput mutational studies; however, this is particularly difficult for the light-activated GPCR rhodopsin. Here, Scott et al. report a fluorescence-based reporter assay in which human rhodopsin is activated in the yeast mating pathway. Their novel yeast-based assay shows similar characteristics as more traditional methods, demonstrating that their engineered yeast strain can be useful in classifying rhodopsin mutants that are consistent with clinical phenotypes.
EDITORS’ CHOICE AWARD IN POPULATION AND EVOLUTIONARY GENETICS
Scott G. Foy, Benjamin A. Wilson, Jason Bertram, Matthew H. J. Cordes, and Joanna Masel
GENETICS April 2019 211: 1345–1355
The current consensus among biologists is that evolution does not have a direction. Here, Foy et al. compare recently-born gene families to genes that are chronologically “more evolved,” finding a striking directionality in the evolution of the structural properties of proteins, which must balance the need to fold in a functional manner against the need to avoid misfolding. Young genes use a primitive strategy to avoid protein misfolding, while old genes use a much more subtle strategy, suggesting a progressive shift in protein folding strategy over billions of years.
EDITORS’ CHOICE AWARD IN QUANTITATIVE GENETICS
Mingzi Xu and Kerry L. Shaw
GENETICS March 2019 211: 1089–1104
A common component of divergence in mating behavior is the distinctive mating songs of insects, and identifying genes underlying natural variation in acoustic behavior is important for understanding targets of selection during speciation. Here, Xu and Shaw examine the largest quantitative trait locus underlying an interspecific difference in the male mating song of two closely related species of Hawaiian crickets, characterize its genetic and phenotypic effects, and refine its map location. They identify an ion channel gene as a promising candidate underlying behavioral isolation between the two cricket species.