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Articles tagged Fundamental Research
(124 results)
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Beyond BRCA: new players in breast cancer pathways discovered
Mutations that disrupt the gene BRCA2 dramatically increase the odds of developing breast and ovarian cancer—but such mutations aren’t enough to cause cancer on their own. To turn normal cells cancerous, some of BRCA2’s genetic interactors must also mutate. In an article recently published in GENETICS, Ding et al. sought to identify some of these genes.…
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Zebrafish offer hope for understanding severe form of epilepsy
The prolonged and severe seizures suffered by those with pyridoxine-dependent epilepsy (PDE) can lead to brain dysfunction and death if not treated. Standard antiepileptic drugs are typically ineffective for people with this rare genetic disorder—instead, they need high doses of vitamin B6 in the form of pyridoxine or pyridoxal 5′-phosphate. But even with this supplementation,…
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Sperm and eggs don’t always join at random
Choosing a mate is hardly random. During courtship in the diploid phase of our life cycle, we often employ elaborate rituals and biological signals to attract and assess potential mates. But after that, we usually assume that eggs and sperm choose each other randomly at fertilization. Or so says Mendel’s First Law. But sometimes, Joseph…
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Benign yeast turn into filamentous pathogens in different ways
The yeast Candida albicans lives on and even inside many of us. Most of the time, its silent presence goes unnoticed, but this fungus can turn on its host, causing infections ranging in severity from annoying to life-threatening. For the yeast to become pathogenic, some of the C. albicans must transform from small, round cells…
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Stressed-out worms hit the snooze button
When you catch a nasty cold, curling up in bed to sleep may be the only activity you can manage. Sleeping in response to stress isn’t a uniquely human behavior: many other animals have the same reaction, and it’s not clear why. While the circadian sleep that follows the pattern of the clock has been…
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Why do so many Nobel Prizes go to scientists working on fruit flies?
As night fell, astronomer Jean Jacques d’Ortous de Mairan watched a plant’s leaves, symmetrically arranged side-by-side on a stem, clamp shut. It was 1729, and he was studying the dramatic nocturnal movement of Mimosa pudica. Strangely, he found that the plant behaved the same way even when it wasn’t exposed to natural cycles of light…
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Clues to the innate drug resistance of a cocoa-fermenting pathogen
At first glance, the yeast Candida krusei seems as innocuous as microbes come: it’s used for fermenting cocoa beans and gives chocolate its pleasant aroma. But it’s increasingly being found as a pathogen in immunocompromised patients—and C. krusei infections aren’t always easy to cure. This yeast is naturally resistant to fluconazole, a first-line antifungal that’s…
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Behind the cover: orchid bee genome
A green, iridescent bee perches on a pink flower, extending its proboscis to reach the sweet nectar inside. He’s not just after a meal—he’s also collecting fragrant substances to store inside his hollow rear legs. Later, he’ll buzz his wings to release the aroma with the hope of attracting a mate. The cover of the…
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How model organism researchers can help solve rare disease puzzles
For many of the roughly 300 million people around the world with rare diseases, the road to diagnosis can be long, painful, expensive, and disheartening. Around eighty percent of very infrequently seen undiagnosed diseases are estimated to have a genetic basis, but even with modern DNA sequencing techniques, the causes are often unclear. In these…
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Alcohol withdrawal is influenced by Slo channels
For people with alcohol dependence, withdrawal symptoms can cause relapse. Some physical symptoms—such as seizures, delirium tremens, and heart rhythm abnormalities—can be fatal, but even non-life-threatening symptoms like anxiety and confusion can trigger relapse. The changes in the nervous system that underlie withdrawal symptoms may involve ion channels in the Slo family. The function of…
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How nematodes sense danger
In critical situations, communication can mean the difference between life and death. If our house goes up in flames, we don’t need to smell smoke to be alarmed as long as someone yells, “Fire!” This isn’t unique to humans; even creatures with much less sophisticated means of sharing information have ways of telling each other…