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Articles tagged Bioinformatics
The most diverse of all human genes encode a set of proteins at the frontline of our immune system. Many different Human Leukocyte Antigen (HLA) proteins are encoded by genes clumped together in one portion of the human genome known as the major histocompatibility complex region. HLA proteins sit on the surface of cells and…
With genomic data from hundreds of thousands of people accumulating, geneticists are now able to mine these data for very rare, but very informative genetic variants, including loss-of-function alleles. For example, across the enormous “reference set” of human exomes announced at the 2014 American Society for Human Genetics Meeting, on average there’s a variant every six bases. In the first of our reports from the ASHG…