Author

Adam Fagen is Executive Director of the Genetics Society of America where he works with the GSA Board to promote the interests of the genetics community and serve the needs of GSA's 5,500+ members. He has a background in genetics, science policy, and science education. (bio)

Nobel Prize

The Nobel Prize in Chemistry has been awarded to three researchers for their mechanistic studies of DNA repair:

  • Tomas Lindahl (Francis Crick Institute, UK) for discovery of base excision repair, which counteracts damage to DNA bases;
  • Paul Modrich (HHMI and Duke University) for demonstrating mismatch repair, which occurs during DNA replication; and
  • Aziz Sancar (University of North Carolina at Chapel Hill) for mapping nucleotide excision repair, the mechanism cells use to repair UV damage to DNA.

 

One of the key papers from Modrich was published in the GSA journal GENETICS.

Pukkila, P. J., Peterson, J., Herman, G., Modrich, P., & Meselson, M. (1983). Effects of high levels of DNA adenine methylation on methyl-directed mismatch repair in Escherichia coli. GENETICS, 104(4), 571-582.

 

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