CRISPR Cleans Up

September 28, 2014

A versatile new CRISPR/Cas9 genome editing strategy allows mutation, tagging, and gene deletion in C. elegans without the use of co-integrated markers or long homology...


In 1979, as the US slid into recession, researchers began systematically crossing eight distinct inbred rat strains. Their goal was to establish a genetically diverse...


Dramatic global declines in amphibians have been linked to the fungal pathogen Batrachochytrium dendrobatidis, but some species are more vulnerable than others. In the latest...


In Stellenbosch, South Africa, in the shade of the university botanical gardens, Adam Wilkins and Richard Wrangham drank coffee and worked their way through a...


One feverish night, just over 100 years ago, an undergraduate in Thomas Hunt Morgan’s lab created the first genetic map. Realizing that the frequency of...


When Scott Alper and colleagues looked for candidate regulators of mammalian innate immunity based on gene expression data, the hit rate was only around 2%....


The Fragile Y

June 18, 2014

Y chromosomes have come and gone many times during evolutionary history. Take beetles. When Heath Blackmon and Jeff Demuth modeled sex chromosome evolution in more than...


For genome-wide association studies, data is power. The more data you have, the more statistical power you wield to find genetic associations. But are there...