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Articles tagged Genomics
(73 results)
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Frog fungus gets lazy in the lab
Amphibians around the world have been devastated by the spread of the deadly fungus Batrachochytrium dendrobatidis (Bd). But although many populations have been decimated, others have survived the same threat. One reason for such different outcomes is variation in virulence between Bd isolates. In the latest issue of G3, Refsnider and Poorten et al. investigate…
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pgEd Briefings: Increasing policymakers’ interest in genetics
Johnny Kung, Director of New Initiatives for the Personal Genetics Education Project (pgEd), fills us in on their latest Congressional briefing. A version of this post is published on the pgEd website and is posted here with permission. On Nov. 17, our group, the Personal Genetics Education Project at Harvard Medical School, held a Congressional…
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The mighty sea squirt
Today’s guest author is Emma Farley, a postdoctoral researcher in Mike Levine’s lab, which recently relocated to Princeton (formerly at University of California, Berkeley). Sea squirts (Ciona intestanalis) are a classic system for the study of development. They were a favorite of early developmental biologists like Laurent Chabry, Ed Conklin, and Thomas Hunt Morgan. Over…
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Read/write access to your genomes? Using the past to jump to the future
Today’s guest author is Razib Khan, who is currently a graduate student in genomics at UC Davis. Outside of his scientific work he is interested in history, religion and philosophy, among other things. You can follow him on Twitter at https://twitter.com/razibkhan. If the story of the last century was the maturation of physical science, the plot of the coming…
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The new genomic world of wild worms
Mark Blaxter (Institute of Evolutionary Biology, University of Edinburgh) reports on the “Caenorhabditis Genomes Project” workshop at GSA’s recent 20th International C. elegans Meeting. Caenorhabditis elegans, affectionately referred to as “the worm,” is one of the prettiest and most informative of the model organisms. It is see-through, has a simple lifecycle and a remarkably simple anatomy,…
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Worm CRISPR Workshop at the International C. elegans Meeting
Technical tips and progress on worm CRISPR/Cas9 genome engineering Today’s guest post was contributed by Mike Boxem, Daniel Dickinson, and Alexandre Paix. Mike Boxem is a group leader at Utrecht University. His interests include technology development, systems biology, and cell polarity. Daniel Dickinson is a postdoctoral research fellow at the University of North Carolina. His interests include…
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A genomic balancing act
Allelic expression in the mouse genome is surprisingly unbalanced, according to new research published in the June issue of GENETICS. The factors that determine how a gene is expressed in a given cell are complex. After all, every mammalian cell contains two copies of each gene, and both versions of that gene, called alleles, play…
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Turning spit and data into treasure
By the time President Obama announced the Precision Medicine Initiative in January 2015, the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort was already a trailblazing example of this new approach to medical research. GERA is a group of more than 100,000 members of the Kaiser Permanente Medical Care Plan who consented to…
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The trouble with HLA diversity
The most diverse of all human genes encode a set of proteins at the frontline of our immune system. Many different Human Leukocyte Antigen (HLA) proteins are encoded by genes clumped together in one portion of the human genome known as the major histocompatibility complex region. HLA proteins sit on the surface of cells and…
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Undergrads power genomics research
With 1014 authors, an article by Leung et al. in the May issue of G3 has the largest author list of any paper published in the journal. More than 900 of those authors were undergraduate students when they performed the research. Over several years, students at 63 higher education institutions across the US conducted an…
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Medaka Genetic Toolbox: Old fish, new tricks
Since the 17th century, the tiny medaka fish that dart through rice paddies in Japan have been bred as living ornaments. Though in the wild they are a nondescript mud color, medaka occasionally turn up in flashier mutant varieties — orange-red, pearlescent white, black splotched — that were much prized by generations of fish fanciers.…