Articles tagged Genome Integrity
(13 results)

The mutations that drive cancer formation are often found in “hub” genes that regulate many aspects of cell growth and survival. But these key genes are not always good therapeutic targets — some are even considered “undruggable.” In the latest issue of GENETICS, Bailey et al. identify a strategy for fighting cancer cells that carry…

Do aging males make poorer quality sperm? Older mothers face a well-established risk of producing eggs with chromosome abnormalities, but it is less clear how age affects meiosis in males. In the February issue of GENETICS, Vrooman et al. investigated chromosome dynamics during spermatogenesis in mice of different ages. They found that meiotic errors increased…