In the search for what drives complex health traits like blood pressure, researchers are looking beyond the genome. While polygenic risk scores (PRS), which estimate a person’s genetic predisposition to a trait based on several variants, offer some predictive power, it’s increasingly clear that integrating environmental and lifestyle factors into predictive models is essential for improving trait prediction. Two new studies published in GENETICS approach this challenge from different angles: one through large-scale statistical modeling, and the other through gene expression analysis in immune cells. Together, they underscore the biological and analytical importance of considering lifestyle in our models of health.

In the first study, Tiezzi et al. investigate whether including lifestyle information can improve the prediction of systolic and diastolic blood pressure, as well as pulse pressure, using data from more than 200,000 older adults in the UK Biobank. Rather than treating environmental variables as static covariates, the authors incorporated 27 lifestyle factors ranging from alcohol intake to physical activity into their polygenic models both with and without adjustments for genetic confounding. Their findings reveal a critical modeling insight: raw lifestyle data can introduce bias due to “reverse causation,” where genetically influenced traits (like BMI or alcohol use) masquerade as independent environmental exposures. When these variables were properly adjusted for, prediction accuracy improved—highlighting the power, but also potential complications, of integrating lifestyle data into polygenic prediction models.

Shifting from prediction to mechanism, in the second paper, Arnold et al. explore how poverty influences gene expression in immune cells and contributes to health disparities. Analyzing blood samples from 204 participants in the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study in Baltimore, Maryland, the researchers found that living in poverty was associated with changes in the expression of 138 genes in peripheral immune cells. Many of these genes are linked to wound healing and coagulation pathways, which are known to contribute to cardiovascular disease and other chronic inflammatory conditions. Two of the genes, EEF1DP7 and VIL1, have also been linked to hypertension in transcriptome-wide association studies, reinforcing a potential connection between poverty-related gene expression and blood pressure regulation. 

Arnold et al. also found that the gene expression effects of poverty were stronger in women than in men, raising further questions about how sex differences modulate environmental stress at the molecular level. Their work builds on existing evidence that socioeconomic status can shape gene expression across immune pathways, with potentially lasting effects on long-term disease risk.

Both studies illustrate the multifaceted relationship between genes and environment, where lifestyle can not only shape disease risk but also confound how we model it. Whether through refined genetic prediction models or gene expression profiling, both studies reinforce the importance of environmental context for understanding complex traits like blood pressure and the social disparities that influence them.

References

Guest posts are contributed by members of our community. The views expressed in guest posts are those of the author(s) and are not necessarily endorsed by the Genetics Society of America. If you'd like to write a guest post, e-mail communications@genetics-gsa.org.

View all posts by Guest Author »

Read more in

  • Thank you, GSA community!

    Thank you for being a member of the Genetics Society of America! As GSA’s current president, I am writing to tell you about Society projects and initiatives that we hope you will find useful in advancing your science and your career. Scientific research is a collaborative and exciting endeavor. Scientific societies like GSA exist to…

  • Collage of 2021 Rosalind Franklin Award recipients

    Where are they now? Rosalind Franklin Young Investigator Award recipients share updates on their research

    Rosalind Franklin Young Investigator Award applications are open–make sure you submit your application or nomination of a colleague by September 30, 2024.

  • University of Minnesota researchers map genome of the last living wild horse species

    The study, published in G3: Genes|Genomes|Genetics, is part of larger conservation efforts to save Przewalski’s horse.

  • Congratulations to the Spring 2024 DeLill Nasser Awardees!

    GSA is pleased to announce the recipients of the DeLill Nasser Award for Professional Development in Genetics for Spring 2024! Given twice a year to graduate students and postdoctoral researchers, DeLill Nasser Awards support attendance at meetings and laboratory courses. The award is named in honor of DeLill Nasser, a long-time GSA supporter and National Science Foundation…

  • Carolyn Damilola headshot

    Carolyn Damilola: an NFS Rising Scientist on a lifelong quest to learn more

    Carolyn Damilola is an NFS Rising Scientist from Nigeria doing respiratory system research and paving the way for scientists from underrepresented communities through mentorship.

  • Text over a blue background image: Apply for up to $2,000 for your project from the Starter Culture Microgrant Program.

    What does a good microgrant proposal look like?

    Members of the Microgrant Review Committee share their tips for a successful proposal.

  • A blurred image of a human face is shown against a dark background.

    The first piece of the facial recognition puzzle

    New research in GENETICS gives a first peek at the molecular pathway involved in recognizing faces.

  • New Senior Editor Amy MacQueen joins GENETICS

    A new senior editor is joining GENETICS in the Genome Integrity and Transmission section. We’re excited to welcome Amy MacQueen to the editorial team.

  • Close up of an adult zebrafish with blue and white stripes in an aquarium with red lighting.

    Block party on the zebrafish sex chromosome

    Research in G3 identifies a gene regulatory block of the zebrafish genome responsible for overseeing the maternal-to-zygotic-transition.

  • Lemna Minor, the common duckweed

    Unraveling the mysteries of duckweed: epigenetic insights from Spirodela polyrhiza

    Research published in G3 offers insight into the impact of DNA methylation on clonal propagation in asexually reproducing plants.

  • Luciano Marraffini headshot

    A microbiologist’s quest to understand CRISPR in bacterial self-defense

    2024 Genetics Society of America Medal recipient Luciano Marraffini determined how CRISPR-Cas systems destroy genetic targets with precision, paving the way for gene editing technology development.

  • Elaine Ostrander headshot

    Unlocking mysteries of trait and disease heritability in dogs

    2024 Edward Novitski Prize recipient Elaine Ostrander, a pioneer of the domestic dog model, discovered numerous genes affecting dog size, morphology, behavior, and disease susceptibility—many of which have relevance in humans.

  • NSF-funded BIO-LEAPS Grant to Support Culture Change in Genetics

    GSA and collaborators Personal Genetics Education & Dialogue and Reclaiming STEM Institute launch NSF-funded BIO-LEAPS project to support culture change in genetics 

    We are thrilled to announce that the Genetics Society of America (GSA) is collaborating with the Personal Genetics Education & Dialogue (PGED) based in the Department of Genetics at Harvard Medical School, and the Reclaiming STEM Institute (RSI) on a Leading Culture Change Through Professional Societies of Biology (BIO-LEAPS) grant from the U.S. National Science…

  • Daman Saluja: Navigating Science and Policy in India

    In the Paths to Science Policy series, we talk to individuals who have a passion for science policy and are active in advocacy through their various roles and careers. The series aims to inform and guide early career scientists interested in science policy. This series is brought to you by the GSA Early Care­er Scientist…

  • Deborah Andrew headshot

    A fly geneticist’s journey into discovering rules of organ development

    2024 George W. Beadle Award recipient Deborah Andrew discovered new genes and pathways in Drosophila salivary gland organogenesis. Now, her work can help optimize cell secretion in therapeutic applications and fight malaria.

  • Małgorzata Gazda's headshot

    Małgorzata Gazda: How receiving the DeLill Nasser Award helped her land her dream job

    Have you ever experienced an event that changes the course of your life, or in this case, your career? Małgorzata (Gosia) Gazda is Assistant Professor at the University of Montreal and in 2022, she received the DeLill Nasser Award for Professional Development in Genetics, which she used to attend and present at the 2022 Population,…

  • Hongyu Zhao joins GENETICS as new Senior Editor

    A new senior editor is joining GENETICS in the Statistical Genetics and Genomics section. We’re excited to welcome Hongyu Zhao to the editorial team.

  • Julio Molina Pineda at TAGC 2024

    GSA Member Julio Molina Pineda Receives DeLill Nasser Award, Shines at TAGC 2024 

    “At any career stage, the GSA membership is an amazing investment for any genetics professional!” Julio Molina Pineda is a PhD Candidate in Cell and Molecular Biology and a Research Assistant at the University of Arkansas, and a Doctoral Academy Fellow at the Lewis Lab. In 2023, Julio was awarded the DeLill Nasser Award for…

  • Ed Grell at his dissecting microscope using ether to anesthetize his flies.

    In Memoriam: Ellsworth Herman Grell (1932–2023), a pioneer of Drosophila genome engineering and annotation

    Ellsworth (Ed) Grell blessed the Drosophila community through three enduring legacies: as a pioneer of chromosome mechanics, as a primary organizer and synthesizer of genetic knowledge in Drosophila, and as a graceful mentor to those fortunate to have known him personally. Ed grew up in rural Nebraska, completed his undergraduate studies at Iowa State, and…

  • Congratulations to the #Fungal24 Poster Award winners!

    We are pleased to announce the recipients of the GSA Poster Awards for posters presented at the 32nd Fungal Genetics Conference! Undergraduate and graduate student members of GSA were eligible for the awards, and a hard-working team of judges made the determinations. Congratulations to all! Felicia Ebot Ojong, The University of Georgia My research is focused…

  • Poster presentation tips for TAGC 2024

    You’ve been selected to present a poster at The Allied Genetics Conference 2024 in March—you’ve celebrated, made plans to attend, now what? This is an exciting opportunity to showcase your research and engage with fellow members of the genetics community, so you want to make sure you’re prepared. We wanted to offer you some tips…

  • Maximize your TAGC 2024 experience 

    A guide to all that National Harbor & DC have to offer Are you joining us for The Allied Genetics Conference 2024 in March? Make the most of your #TAGC24 experience in National Harbor! We know the science will keep you busy, but you deserve to unwind and have some fun, so we’ve curated a…

  • Early Career Leadership Spotlight: Sarah Petrosky

    We’re taking time to get to know the members of the GSA’s Early Career Scientist Committees. Join us to learn more about our early career scientist advocates. Sarah PetroskyMultimedia SubcommitteeUniversity of Pittsburgh Research Interest I am interested in understanding adaptation that has been happening recently in populations by dissecting the ways that genes underlying an adaptation…

  • TAGC 2024 Early Career Award Winners

    GSA is pleased to announce the winners of the early career awards presented at The Allied Genetics Conference 2024. These awards are specific to particular TAGC communities and recognize early career scientists’ outstanding work on their respective research organisms. The awardees will present their talks in keynote sessions at TAGC 2024.  Don’t miss the opportunity…

  • Preeminent geneticists recognized with revamped GSA Awards

    In 2022, GSA’s Board of Directors launched an audit to review the five major awards conferred by the Society. Today, we are thrilled to announce the recipients of the reimagined GSA Awards, including the new Genetics Society of America Early Career Medal. The scientists honored this year are recognized by their peers for their outstanding…

  • Fly Board funds outreach programs to spread the word about Drosophila research

    In 2020, the Fly Board voted to use part of its reserve fund to support efforts to increase trainee participation as well as equity and diversity in the Drosophila community. An awards committee decides how the money will be spent each year, and from 2020–2022, the committee posted a very broad call for applications from…

  • New members of the GSA Board of Directors: 2024–2026

    We are pleased to announce the election of four new leaders to the GSA Board of Directors: 2024 Vice President/2025 President Brenda Andrews Professor, University of Toronto It’s an honor to continue my association with the Society by serving as Vice President of the Board of Directors. I have broad knowledge of the ongoing activities…

  • Policy changes are closing the door on the “American Dream”

    The American Dream once promised that talent and hard work could open doors. For early career scientists, those doors are now closing. Research is being paused or studies outright canceled, funding delayed or completely pulled, and careers cut short—not because of bad science, but because of changing political priorities. Researchers are being forced to choose: leave science or leave the country. These setbacks send a clear message: the U.S. commitment to supporting the next generation of scientists is waning.

  • Congratulations to the Worm 2025 GSA Poster Award Recipients

    We are pleased to announce the GSA Poster Award recipients from the 25th International Worm Meeting! Undergraduate and graduate student GSA members were eligible for these awards, and a hard-working team of judges made the determinations. Congratulations to all! Special thanks to our Poster Chairs Tina L. Gumienny (Texas Woman’s University), Jared Young (Northeastern University),…

  • GENETICS Expands Primers Section

    Beth De Stasio of Lawrence University will serve as Senior Editor and work with a newly formed team of six Associate Editors to expand the publication of Primers in GENETICS.