Analysis of insulin-like signaling in C. elegans reveals extensive positive and negative feedback regulation. The insulin-like signaling system of nematode worms is comparable to that...


Apoptotic pathway promotes asymmetric cell division during C. elegans development. Cell division doesn’t always produce identical daughter cells; often, the demands of multicellular development require...


A Wnt protein involved in the formation of the human ovary plays an important role in female zebrafish sex development.    Even though zebrafish are...


Holes in the plasma membrane trigger the activation of the Torso receptor tyrosine kinase. As a general rule, cells don’t do well when holes are...


A fruit fly model of fetal alcohol spectrum disorder reveals a Cyclin E-centric network modifies developmental sensitivity. Alcohol exposure in utero can lead to a...


Fruit fly mutants can sometimes be grisly. Ecdysteroid hormones control aspects of fly development, including molting and metamorphosis; because aberrations in these genes lead to...


Why study human diseases in frogs? For starters, 79% of genes implicated in human disease have orthologs in the African clawed frog Xenopus laevis. Frogs...


The Genetics Society of America’s Edward Novitski Prize recognizes a single experimental accomplishment or a body of work in which an exceptional level of creativity...


In the 1940s, C. H. Waddington discovered a peculiar phenomenon in fruit flies: traits could appear in response to environmental stress in an individual’s lifetime...


Guest post by Pamela K. Mulligan and Susanne M. Gollin. Robert C. King, Professor of genetics at Northwestern University for over four decades and a pioneer...