Articles tagged Genetics Journal
(305 results)

Guest authors C. Brandon Ogbunugafor and Rafael F. Guerrero demystify higher order epistasis through a short story about the perfect brew. Epistasis is the flavor of the month Epistasis is one of the most popular and provocative topics in modern genetics. It has many different definitions, but one especially useful one is that epistasis is…

Improved duplex sequencing identifies spontaneous mutations in bacteria without long-term culturing. Spontaneous mutations are the driving force of evolution, yet, our ability to detect and study them can be limited to mutations that accumulate clonally. Sequencing technology often cannot identify very rare variants or discriminate between bona fide mutations and errors introduced during sample preparation.…

Analysis of insulin-like signaling in C. elegans reveals extensive positive and negative feedback regulation. The insulin-like signaling system of nematode worms is comparable to that of more complex organisms; it helps regulate a wide range of the animal’s biology, including metabolism, growth, and development. This system is remarkably flexible, with the ability to maintain a…

Apoptotic pathway promotes asymmetric cell division during C. elegans development. Cell division doesn’t always produce identical daughter cells; often, the demands of multicellular development require cells to split into two quite different daughters with quite different fates. These “asymmetric” divisions are needed so that cells can differentiate and specialize, and some cells are even programmed…

A better way to make endogenous reporters in C. elegans CRISPR systems for gene editing have revolutionized biological research, but the method still has limitations. While it is usually straightforward to delete parts of the genome using CRISPR, large insertions can be a challenge. This has been the case even for the nematode Caenorhabditis elegans,…

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2018. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors. Browse the 2018 GENETICS Spotlight.   Browse the 2018 G3 Spotlight.

A landmark paper published in GENETICS founded the field of genomic prediction before the requisite technology was available. When a new technology is developed, it can allow scientists to make great strides in addressing longstanding questions. Occasionally, however, researchers think so critically about a knowledge gap in their field that they’re able to propose a…

Congratulations to the winners of the Editors’ Choice Awards for outstanding articles published in GENETICS in 2018! The journal’s Editorial Board considered a diverse range of articles, finding many papers worthy of recognition. After much deliberation, they settled on one exceptional article for each of the three award categories: molecular genetics, population genetics, and quantitative genetics. Check out…

A Wnt protein involved in the formation of the human ovary plays an important role in female zebrafish sex development.    Even though zebrafish are a well-studied research model, how these fish develop into males or females remains rather obscure—in part because the sex of lab strains is not determined by sex chromosomes. Research published…

An opportunistic human pathogen makes itself at home on old oaks. At one point or another, most people have played host to the common yeast Candida albicans. Around 40-60% of healthy adults carry around it in their mouth or guts; in immunocompromised people, however, this normally harmless cohabitant becomes a deadly pathogen. Generally thought to…

Guest author Amir Teicher discusses how the concept of “genetic load” traces its roots back to eugenic thinking, as described in his recent Perspectives article in GENETICS. The possibilities opened up by advances in genome sequencing have recently spurred discussions on the burden, or cost, that mutations pose to organisms and populations. Does the relaxation…