Articles tagged Drosophila
(122 results)

Registration is now open for the 60th Annual Drosophila Research Conference! In the fall of 1958, a handful of colleagues met to talk “more or less endlessly” for two days, mainly about the fruit fly Drosophila. Most of the dozen or so participants were members of James F. Crow’s laboratory at the University of Wisconsin–Madison.…

Guest post by Andreas Prokop. This blog post was originally published as an article in Open Access Government (Prokop, 2018b) to advocate for the importance of Drosophila research. It follows up on a previous piece in the same journal advocating for developmental biology (Prokop, 2018a). These articles aim to showcase how policy and decision makers…

A new collection of inbred flies provides a tool for studying genetic control of sleep. Sleep is vital for a healthy life, but some of us seem to get by with less snoozing than others. This individual variation isn’t unique to humans; fruit flies also show a variety of sleep patterns. These differences could potentially…

Low-cost sequencing closes gaps in fly genomes. Genetic sequencing technologies have revolutionized biological science, and regular advances in these tools continue to deliver better genomic data—more accurate and more useful—at a lower cost. In G3: Genes|Genomes|Genetics, Miller et al. report the genomes of 15 Drosophila species sequenced using Oxford Nanopore technology. Their work improves on…

Holes in the plasma membrane trigger the activation of the Torso receptor tyrosine kinase. As a general rule, cells don’t do well when holes are poked in their plasma membranes. That’s why many immune cells use enzymes like perforin to puncture the membranes of pathogenic cells, dysregulating and often killing them. However, a new report…

A fruit fly model of fetal alcohol spectrum disorder reveals a Cyclin E-centric network modifies developmental sensitivity. Alcohol exposure in utero can lead to a wide range of developmental problems, even causing fetal death in some cases. But since this exposure doesn’t always have the same outcome, is it more likely to be a problem…

Bruce Stewart Baker—the geneticist whose work uncovered molecular mechanisms of Drosophila sex determination and dosage compensation—died unexpectedly on July 1, 2018. He was 72. Bruce Baker was born on Dec 20, 1945 to William K. (Bill) Baker—also a renowned Drosophila geneticist —and Margaret I. Stewart in Swananoa, NC, the site of the closest army hospital…

An automated drug screening approach gives insight into rare NGLY1 deficiency. Sometimes, diagnosing and treating an illness is straightforward. Other times, the diagnosis is challenging while the treatment is simple—or vice versa. In the case of a rare disease like NGLY1 Deficiency, both diagnosis and treatment can feel unreachable. The complex challenges of rare diseases…

New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including increased numbers of single nucleotide variants (SNVs) and copy number variants (CNVs). However, a 2014 study on a fruit fly tumor detected no elevation of SNVs or CNVs compared to non-tumor…

Offshoot of the modENCODE project provides crucial data and strains for understanding gene regulation. Following a multidisciplinary effort spanning six institutions, researchers working on the modERN (model organism Encyclopedia of Regulatory Networks) project have released a powerful resource for biologists studying the fruit fly Drosophila melanogaster and the nematode worm Caenorhabditis elegans. So far, report Kudron,…

A new fruit fly model of Leigh syndrome reveals the importance of mtDNA variation. Inherited mitochondrial disorders pose a perplexing problem to researchers and clinicians: people with the same condition can have vastly different clinical manifestations, even if they share the same mutation. For example, a neurodegenerative disorder called Leigh syndrome, which can be caused…