A fisherman trying to catch rainbow trout (Oncorhynchus mykiss) needs the right tools: proper flies, a strong rod, and a little bit of know-how. A...


Short-read sequencing has fueled the acceleration of genetic research But though these next-generation methods are fast and efficient, they can’t do everything well. One important...


If you’ve ever watched a procedural crime-solving show on television, you’re sure to have seen a lab tech magically produce results from a complicated assay...


Over the last decade, advances in next-generation sequencing technology have given rise to many findings increasing our understanding of human disease and natural variation within...


Primary ciliary dyskinesia (PCD) is a disorder characterized by chronic respiratory distress that has a history of going undiagnosed. Combined whole-exome sequencing (WES) and copy-number...


For Lake Whitefish, history has repeated itself. Across the St. John River region that spans Québec and Maine, these freshwater fish have continually evolved in...


The most diverse of all human genes encode a set of proteins at the frontline of our immune system. Many different Human Leukocyte Antigen (HLA)...


Assembling a Colossus

January 16, 2014

The loblolly pine genome is big. Bloated with retrotransposons and other repetitive sequences, it is seven times larger than the human genome and easily big...