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CRISPR Cleans Up
A versatile new CRISPR/Cas9 genome editing strategy allows mutation, tagging, and gene deletion in C. elegans without the use of co-integrated markers or long homology arms, report Paix et al. in an article published Early Online in GENETICS. The strategy can be easily scaled up, and should allow systematic construction of precise ORF deletions and…
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Fine-Mapping Diabetic Traits with Outbred Rats
In 1979, as the US slid into recession, researchers began systematically crossing eight distinct inbred rat strains. Their goal was to establish a genetically diverse rat colony to serve as a base for phenotype measurements and artificial selection. But the creators of the NIH rat Heterogeneous Stocks (HS) faced major challenges: “…the main one being…