Articles tagged Zebrafish
(15 results)

Laboratory zebrafish hide a dirty little secret. Although the tiny fish have proven to be a vital model of vertebrate development and disease genetics, zebrafish reproduction—at least in the lab—has wildly variable outcomes. Offspring sex ratios can vary from extremely male-biased to extremely female-biased, depending on which breeding pairs serve as parents. The reason for…

In this month’s editorial, the Editors of GENETICS invite submissions of human genetics research articles. To kick off the journal’s call for papers, the October issue features an article by Brooks and Wall et al. identifying the cause of a single-family disorder and a commentary by Phil Hieter and Kim Boycott on the power of model organisms…

Zebrafish develop fast. They are conveniently small. Their embryos are stunningly transparent. But despite their many powerful advantages as a genetic model, they have a drawback that complicates the use of methods like CRISPR, morpholino knockdown, and RNAseq: they are not great inbreeders. Because inbred zebrafish stocks tend to be sickly, most research relies on…

The medaka, or Japanese rice fish, is a century-old genetic model on the rise again. Long studied by scientists in Japan, it has been rediscovered by the wider research community over the last decade as a flexible tool for vertebrate genetics. Part of the appeal is the medaka’s amenability to inbreeding. In the latest issue…