A suppressor screen in C. elegans uncovers previously unknown flexibility in the genetics underlying extracellular membranes. In nearly all animal tissues, thin barriers called basement...
C. elegansFundamental ResearchGenetics JournalModel Organisms
New evidence for genome instability in fly tumors suggests key similarities—and differences—from human disease processes. Human cancers display a variety of abnormal genomic features, including...
Cancer GeneticsDrosophilaFundamental ResearchG3 JournalHuman DiseaseModel Organisms
Offshoot of the modENCODE project provides crucial data and strains for understanding gene regulation. Following a multidisciplinary effort spanning six institutions, researchers working on the modERN...
C. elegansData & DatabasesDrosophilaGene ExpressionGenetics JournalModel Organism DatabasesModel Organisms
A new fruit fly model of Leigh syndrome reveals the importance of mtDNA variation. Inherited mitochondrial disorders pose a perplexing problem to researchers and clinicians:...
DrosophilaFundamental ResearchGenetics JournalHuman DiseaseModel OrganismsRare Diseases
After 60 years of mystery, researchers have identified the pathogen responsible for White Fat Cell Disease. Water fleas of the genus Daphnia have long been...
Yeast and zebrafish are among the lab organisms being recruited to the search for rare disease cures. Rare diseases are not so rare. About 300...
Biologists rely on animal models to answer important questions that can’t be addressed with cells in a dish. Often, these animals are deliberately inbred; a...
BioinformaticsComplex Traits & Quantitative GeneticsG3 JournalMammalsModel OrganismsMouse & RatPopulation GeneticsReproducibility
Consider the papercut—a minor injury best known for the disproportionate amount of pain it can cause. That a wound so inconsequential can sting so terribly...
C. elegansFundamental ResearchGenetics JournalModel Organisms
Beer, doughnuts, and genetics textbooks have one thing in common: they were all made possible by collaborations between humans and yeast. Our fungal ally Saccharomyces...
Fundamental ResearchG3 JournalHuman DiseaseImmune SystemInsectsModel OrganismsYeast
Why study human diseases in frogs? For starters, 79% of genes implicated in human disease have orthologs in the African clawed frog Xenopus laevis. Frogs...
CRISPRDevelopmentGene EditingGenetics JournalModel OrganismsXenopus
